Gender-diverse youth, including transgender, non-binary, and gender-nonconforming youth face many significant issues that affect their wellbeing and development. These issues include stigma, discrimination, access to gender-affirming care, and impacts on their social support systems. This training reviews social determinants of health specific to gender-diverse youth, including those related to mental health, substance use, and safety. The training will also illustrate best practices according to the latest research in supporting gender-diverse youth most effectively, including relational and family considerations. This training is intended for field-based mental health and outreach workers in Los Angeles County.