Perinatal substance use disorders (SUDs) affect up to 10% of pregnant and newly postpartum people. An enormous amount of stigma and shame prevents many of these patients from seeking much-needed care. This is the second of a two-part series exploring the epidemiology, presentations, and treatments for specific substances commonly used in Los Angeles County, including alcohol, cannabis, methamphetamine, and opioids. In particular, we will review the most current evidence-based practices for medication-assisted treatment, where they are available, and what we know about their safety data in pregnancy and breastfeeding.